Search on: 2-5A SYNTHETASE 
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Descriptor English:   2',5'-Oligoadenylate Synthetase 
Descriptor Spanish:   2',5'-Oligoadenilato Sintetasa 
Descriptor Portuguese:   2',5'-Oligoadenilato Sintetase 
Synonyms English:   (2'-5')An Polymerase
2',5'-Oligo(A) Polymerase
2',5'-Oligo(A) Synthetase
2,5 Oligoadenylate Polymerase
2,5 Oligoadenylate Synthetase
ATP-(2'-5')oligo(A)adenylyltransferase
2',5' Oligoadenylate Polymerase
2',5' Oligoadenylate Synthetase
Oligoadenylate Polymerase, 2,5
Oligoadenylate Synthetase, 2,5
Polymerase, 2',5'-Oligoadenylate
Polymerase, 2,5 Oligoadenylate
Synthetase, 2',5'-Oligoadenylate
Synthetase, 2,5 Oligoadenylate
2',5'-Oligoadenylate Polymerase
2-5A Synthetase  
Tree Number:   D08.811.913.696.445.625
Definition English:   An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions. 
History Note English:   83 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   21042 
Unique Identifier:   D015088 

Occurrence in VHL: 		 

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